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Top Medical Discovery of 2007 Explained via Cartoon

For a long time, it seemed as if a medical discovery that Science called "one of the greatest of 2007" might never get covered by the mainstream media because it was just too complicated. But then an enterprising journalist and artist with the Philadelphia Inquirer boldly went where no reporters dared go. Writer Tom Avril and artist Cynthia Greer figured out how to simplify this complicated discovery into a completely-accurate cartoon (pictured).

A researcher named Steven Reiner at University of Pennsylvania proved that the human body fights disease with two kinds of immune cells (called T-cells): some that fight the invading microbes, and some that exist just to keep a record of how to fight those microbes in the future. Those "memory" cells are what this researcher revealed, and their mysteries are still being unlocked.

Writes Avril:

The University of Pennsylvania physician electrified his field last year by showing how the immune system generates two types of the sophisticated tools known as T-cells: one to fight invaders to the death, the other to remember the battle plan for the next time the same enemy shows up.

Reiner's finding, made with John Chang, Vikram Palanivel and colleagues, was named one of the top 10 breakthroughs of 2007 by the journal Science. Using mice, the team provided evidence that T-cells arise from a self-renewing process a bit like that used by stem cells. Without it, we'd fight off a bug once, and the next time we'd be dead.

"It's an amazing system," Reiner marvels. "You do use these cells, but you don't deplete them. That's how we can live long lives with short-lived cells."

I love it when somebody figures out a simple way to explain such a crucial issue to the public. Want to get really complicated about it? Read one of Reiner's published papers.

Making Immune Memories [via Knight Science Journalism Tracker]

3:00 PM on Wed Mar 26 2008
By Annalee Newitz
3,834 views
17 comments

Comments

  • It would be cool if all scientific discoveries came with a simplified artistic rendition of the discovery. 'Twould be more fun!

  • First sentence there needs the word 'if' added, kinda confusing otherwise.

  • 2007? More like 1987. What Reiner et al. elucidated was the mechanics of this system. But all the information in that cartoon appears in any immunology text from the mid-90's on. Elegant work, but just one piece of the puzzle.

  • @foolish-rain: The sad fact is that no medical breakthrough is ever really more than an elegant piece of the puzzle. Still, I think it's well done.

  • I honestly thought that the existence of those "memory cells" were already established; I guess it was just theory at the time.

  • I was under the impression that memory cells were already established fact as well, I learned about them about a year ago now in my immunology class.

  • I too learned it this previously...

    and like all good medical students I learned it twice and forgot it three times..

    The discover was "showing how the immune system generates two types of the sophisticated tools known as T-cell"...

    We knew it happened.. we apparently did not have some detail of how it happened...

    But not to diss this discovery or it cartoon version.

    I am always in favor of trying to spread science to the masses...

  • @DocGratis: Exactly -- the discovery was showing how it works, not proving their existence.

  • T-cell. Presumably closely linked to the t-virus? I can't see this ending well...

  • No matter how this stuff works, it needs to be ramped up big time with the addition of nanocytes. If we can filter the internet with it's hundreds of billions of bits, then we should be able to filter our bodies too. Hey, it's all just information.

  • Since the Fighter T-cells are green, do Vulcans have more of them?

  • Wesman, the answer is YES! And you win today's prise: An io9 T-shirt. Just tell use your size and what color. You get to pick black or black.

    I'd buy one.

  • If any one is intrested here is the abstract from SCIENCE:

    A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.

    Shame I can't post the entire article

  • THIS is the greated medical discovery of 2007? I learned about this in highschool back in 1996.

    Seriously, wtf...

  • Now if someone could only provide a handy illustration of the labyrinthine X-Files mythology...

  • @Chiper:
    I thought the same thing too, but it should be remebered that its how it happens that memory and effector T cells are developed. Before this work it was thought that either (A) different ways the immune system sees pathogens and vaccines cause effector or memory formation in T cells or (B) that memory T cells evolve after the collapse of the effector cell population in the resolution of infection.

    What this article show as far as I understand it is that is its neither, but option (C). After simulation by the dendritic cell, the T cell will divide into two daughter cells that are functionally different. This was not expected- what was expected is that they would be exactly the same.

    Here is a pubmed link to the actual paper: [www.ncbi.nlm.nih.gov]


  • @Jeff-Minor: Extra Large. And can I get a black one? My life will then be complete. Shoot me, stuff me, and sit me on the mantel.

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