Pre-Darwin, this was a big deal. If a deity was crafting species ex nihilio, the messiness of interbreeding posed some question about what really counted as a "kind." Darwin pointed out in the conclusion of the "Origin of Species," that in light of his (and Wallace's) discoveries, that was kind of a waste of time. Everything was interrelated, so occasionally interbreeding capability between two apparently different organisms was something to expect from time to time.
During WWI, London was raided by bomber Zeppelins, and they were sufficiently hard to shoot down, even with burning magnesium incendiary rounds, that the British were convinced the hydrogen gas envelopes were surrounded by inert nitrogen bags. It's a fine idea, but it wasn't true. Sending a chunk of burning metal into the anaerobic environment of the inside of a gas bag certainly didn't cause fires, and the gas from previous punctures dispersed too quickly to generally ignite and was too low energy to cause major damage when it did. Eventually the British started dropping bombs on them from above in combination with incendiary strafing. The stuff finally burns if you tear away half the envelope...
The Hindenburg was scrupulously designed to avoid fire. While the hydrogen certainly burned, and may even have been the first substance ignited, the spectacular nature of the fire was mostly a product of having tremendous amounts of surface area, thin materials, and lots of diesel fuel, because, as mentioned, hydrogen fires are not terrible visible. In the end, two-thirds of the passengers lived, an oft-overlooked fact, likely because the burning hydrogen transported heat away from the passenger compartments at the keel. It was an awful accident to be sure, but in a word, shit happens. It was not of an unprecedented scale in terms of casualties then or now. It just so happened to happen in front of the cameras, produced a hell of a show, and just so happened to arrive as airships were on the verge of being marginalized by airplanes, whose development was accelerated by WWII. There's more poetry than engineering lessons in the Hindenburg-especially considering that if you still are eager to implicate the hydrogen cells, they would have been filled with helium had the US not been refusing to sell it (the global supply comes from Texas) to the fascists. Making a really safe hydrogen airship these days wouldn't be too terribly difficult, and various groups have done some work in that vein, seeing as helium is something of a limited resource.
All the GAO findings and such have suggested that NASA is actually rather efficient. At the per item level, big science is always expensive- and the estimated discounted return rate on NASA related tech development isn't trivial- it's 33%. Try finding other investments that solid.
It could also suck really bad, because the thing is so borderline harrowing with the unpleasant people doing unpleasant things, as it stands in print that it isn't hard to imagine that with a viewpoint placed a little too close to the action that it could turn into one of Those Movies, where the nastiness appeals a bit too much to prurient interests for my tastes.
More trouble will come of it simply being bleak as all hell in a way that might simply be too oppressive on screen.
I'm merely suggesting that, firstly, Dune and Co., as written, are more "Foundation" than "Dhalgren" and that spice is as much MacGuffin as theme (especially when Paul's visions are lamented as terrible dead ends for another two books and then the industrial replacement of all the uses of spice is undertaken for another two.)
Secondly, I posit that the reason that Dune on film has variously sputtered or failed to impress is largely because directors (Lynch and Jodorowsky) with an affinity for pseudocryptic exercises (which I am uniformly fond of, I should add) attached themselves to said projects primarily because of the opportunities for said exercises offered by the neogothic pomp and the psychedelia and proceeded to throw away the majority of the book that consists of chess played with spies, fanatics, ecosystems, Cretan paradoxes and very long knives, and that their work suffered as a result.
No indictment of prehistorical shamanism, analytical fallacies, or misunderstanding of the adaptation process contained within.
If you haven't followed some links, really do some exploring. Jodorowsky had Paul dreaming Arrakis out of orbit, after his death, to shine the light of higher consciousness throughout the galaxy and Emperor Dali, living with his replicant on an all gold planet, holding court while crapping on a toilet throne made from dolphins. He didn't get what the hell the whole thing was about.
But- and this is half of what makes us tolerate said nastiness- is that it all fits into a nice bucket of metal oxides in a world full of places to dig very secure holes. The default mode of a coal fired power plant is to put undesired nastiness everywhere in quantities of a scale larger than that of nuclear plants by roughly the scale in difference in energy delivered from a chemical vs. a nuclear reactor- planet-scorching CO2, sulphur and nitrogen oxides, fly ash, and even sequestered radioisotopes. Nukes are fundamentally tidy. A nuclear reactor will fundamentally work as a magical black box for twenty to thirty years, taking and and discharging nothing, and at the end of it, you have to make a cave about the volume of the reactor core, pay attention to the flow of groundwater, and lock the door behind you. And that's not too bad.