I think Reynolds' books are part of the reason I was drawn to the Mass Effect universe in the first place. They have so much in common.
But I do think that Mass Effect is the greatest non-book SF universe of my generation. (I was born in 1984, so Trek and SW don't count. Just throwing that out there, 'cause someone's bound to bring it up.)
BTW, does Reynolds ever plan to tie up the loose ends in the Revelation Space universe? We seriously never find out about the Madame. Plus, all those other mysteries you mention. Also, I want to know if humanity-- or any other sentient race-- ever manages to stop the greenfly.