The experiments were undertaken on patients who already had electrodes in their brain to monitor epilepsy. Readings were taken via electrocorticography (ECoG), as the subjects were shown a grid of letters and numbers. As each symbol was illuminated, the patient was told to focus on the letter or number, and data was recorded. Once this calibration data was taken, the patients would think of a letter or number, and their brain waves would be appropriately translated to the screen. The theory is that this technique will allow people to communicate and type far more easily when they suffer from Lou Gehrig's disease, MS, or paralysis.

The lead scientist on the project, Dr. Jerry Shih, says the program is able to perform near or at 100% accuracy for the patients. While this isn't far from the results from studies using non-invasive EEG, Shih believes that ECoG has advantages, as the scalp and skull distort the information coming from the brain, which means that ECoG has potential to be faster and more accurate. Shih also said that with EEG, "the accuracy isn't terribly great, and it takes a long time for the computer system to learn an individual's brain signals and to correctly interpret."

It is early days yet, and there are still numerous hurdles for the research. The initial study was only with two patients, but they're now on to the sixth, with plans for a wider study, to ensure that this technique is universally applicable. Shih's system does require a craniotomy, which is not a surgery to be taken on a whim; and an interpreter device is required, which must be tuned to an individual user. There is also the fact that EEG based interfaces don't require the invasive surgery, and are similarly accurate, even if they are slower and not quite as precise. So in terms of market adoption, the implant is at a disadvantage. Most people would be willing to deal with the speed loss to avoid dangerous procedures.

Shih is currently working on ensuring the method's effectiveness. He believes it could be used for controlling prosthetics as well as typing. It could also possibly be trained with images instead of letters. Imagine an item, and an image or word for it would appear on your screen.

The device could be available in as little as 5-10 years.

It's just a matter of time before this technology filters down from medical to elective, and we can all live out our cyberpunk dreams of plugging our brains directly into a computer.

Via American Epilepsy Society and Mayo Clinic

1. We can erase people's memories.
Back in October a study was published in Neuron that proved an enzyme called CaMKII can erase bad memories while you recall them. In Dollhouse, the "actives" have their own memories erased first, and then new memories implanted. The brain-erasure technology is actually the cornerstone of the operation, as it's what turns the actives into blank slates ready to be reprogrammed. Right now, with the cooperation of desperate people, scientists could be using CaMKII to erase their old lives. Then they'll just need to implant new personalities and emotions.

2. We can regulate people's moods with microchips.
Right now, there are a series of implantable microchips on the market that send out electrical impulses over your nerves that can soothe a depressed person or reduce seizures. Some call them neurological pacemakers, and we are discovering new things about them every day - such as the fact that some can cause instant orgasm. Wipe somebody's brain, then install these brain pacemakers, and you might start shaping a whole new person by controlling what gives them pleasure and what makes them depressed.

3. We can use brain implants to steer animals left and right.
Several years ago, neuroscientists invented a little rat-sized brain implant that sent directional signals to the rodent's brain. Using a handheld remote, scientists sent electrical signals to the parts of the rats' brains connected to right and left whisker sensations - and could induce the rats to turn right or left at the press of a button. Dubbed the "robo-rat," the creatures could be used for complicated search and rescue efforts that require crawling into small places. Or they could be the beta version for a more nefarious technology implanted into humans' brains that would allow a corporation like the Dollhouse to remote-control an active's every move, right down to which street they turn on.

4. Infrared brain scans can predict what people want.
As we reported last week, researchers have discovered that a simple infrared brain scan can reveal patterns in brain activity that show simple preferences. Ask a person whether they'd rather have a dog or a cat, and this scan will give you the answer. This is the first step towards knowing how to shape people's preferences. If scientists could trigger a reaction in your brain that reversed the pattern, they might be able to turn a cat person into a dog person and vice versa.

5. Human-computer interfaces link human brains directly to computers.
You may have heard of BrainGate, a technology that uses electrodes sunk into your gray matter to convert electrical impulses from your brain into computer commands. It is currently used by people who are profoundly paralyzed to communicate by moving a cursor around. If we can open up communication between brain and computer like that, it stands to reason that the communication might be two-way. Who is to say there is no secret organization using a BrainGate-esque technology to reprogram people's thoughts?

What's particularly interesting about this research is that it shows the versatility of the motor cortex when combined with a brain-computer interface (BCI). Previous research showed that people could learn to move a cursor on screen by linking to specific areas of the motor cortex. This new study showed that any area of the motor cortex could be "repurposed" to activate muscles in the body via BCI.

Say the researchers:

Until now, brain-computer interfaces were designed to decode the activity of neurons known to be associated with movement of specific body parts. Here, the researchers discovered that any motor cortex cell, regardless of whether it had been previously associated with wrist movement, was capable of stimulating muscle activity. This finding greatly expands the potential number of neurons that could control signals for brain-computer interfaces and also illustrates the flexibility of the motor cortex.

Human implementations for the technology are at least a decade away, but this discovery could be a game-changer for dealing with paralysis. One possibility would be to connect the motor cortex with an area of the spine below an injury. Signals would be re-routed around the damaged spinal cord, and could allow the brain to regain control of the paralyzed body parts affected by the injury.

Image via Cortech Solutions.

Direct Control of Paralyzed Muscles by Cortical Neurons [via Nature]