<![CDATA[io9: mad+science]]> http://tags.lifehacker.com/assets/base/img/thumbs140x140/io9.com.png <![CDATA[io9: mad+science]]> http://io9.com/tag/madscience http://io9.com/tag/madscience <![CDATA[A Device That Lets You Type With Your Mind]]> By placing electrode grids inside patients' skulls, researchers at the Mayo Clinic have created a way for people to type words using only their brainwaves. It's a major breakthrough for brain-computer interface research.

The experiments were undertaken on patients who already had electrodes in their brain to monitor epilepsy. Readings were taken via electrocorticography (ECoG), as the subjects were shown a grid of letters and numbers. As each symbol was illuminated, the patient was told to focus on the letter or number, and data was recorded. Once this calibration data was taken, the patients would think of a letter or number, and their brain waves would be appropriately translated to the screen. The theory is that this technique will allow people to communicate and type far more easily when they suffer from Lou Gehrig's disease, MS, or paralysis.

The lead scientist on the project, Dr. Jerry Shih, says the program is able to perform near or at 100% accuracy for the patients. While this isn't far from the results from studies using non-invasive EEG, Shih believes that ECoG has advantages, as the scalp and skull distort the information coming from the brain, which means that ECoG has potential to be faster and more accurate. Shih also said that with EEG, "the accuracy isn't terribly great, and it takes a long time for the computer system to learn an individual's brain signals and to correctly interpret."

It is early days yet, and there are still numerous hurdles for the research. The initial study was only with two patients, but they're now on to the sixth, with plans for a wider study, to ensure that this technique is universally applicable. Shih's system does require a craniotomy, which is not a surgery to be taken on a whim; and an interpreter device is required, which must be tuned to an individual user. There is also the fact that EEG based interfaces don't require the invasive surgery, and are similarly accurate, even if they are slower and not quite as precise. So in terms of market adoption, the implant is at a disadvantage. Most people would be willing to deal with the speed loss to avoid dangerous procedures.

Shih is currently working on ensuring the method's effectiveness. He believes it could be used for controlling prosthetics as well as typing. It could also possibly be trained with images instead of letters. Imagine an item, and an image or word for it would appear on your screen.

The device could be available in as little as 5-10 years.

It's just a matter of time before this technology filters down from medical to elective, and we can all live out our cyberpunk dreams of plugging our brains directly into a computer.

Via American Epilepsy Society and Mayo Clinic

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<![CDATA[Talk Monkey to Me: Monkey Language Contains Simple Sentences]]> While other primates have exhibited simple vocabularies, it has long been believed that syntax, the construction of sentences, was unique to humans. But a recent study suggests that at least one species of monkey communicates in vocalized sentences.

A research team led by Klaus Zuberbühler of the University of St. Andrews has been studying the calls of the Campbell's monkey, a primate found in the Ivory Coast. The team looked at how the calls of adult male monkeys vary in response to various stimuli. Campbell's monkeys have six different types of individual calls, each of which has a distinct meaning. What's surprising, however, is that these monkeys actually string together multiple types of calls to create communications with entirely new meanings. Zuberbühler and his team claim this is a form of syntax, suggesting that Campbell's monkeys have developed a sort of sentence structure. Other primates, such as chimpanzees, have shown an understanding of language, able to connect words and symbols with specific meanings, but haven't been able to combine those words into sentences.

The team has identified the meanings of the individual calls, as well as how they can be combined to form completely different communications:

The "boom-boom" call invites other monkeys to come toward the male making the sound. Two booms can be combined with a series of "krak-oos," with a meaning entirely different to that of either of its components. "Boom boom krak-oo krak-oo krak-oo" is the monkey's version of "Timber!" - it warns of falling trees.

Combining the "boom-booms" and "krak-oos" with a third sound, "hok-oo," warns monkeys of the presence of other monkey groups. It appears that initially, the monkeys developed the calls to warn each other of specific predators, such as leopards and eagles, but their anti-predator vocabulary has evolved into something much more sophisticated.

Boom! Hok! A Monkey Language Is Deciphered [NY Times]

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<![CDATA[Charting the Possible Evolution of Same-Sex Liaisons]]> Same-sex sexual behavior has evolved multiple times in various animals, including mammals, birds, fish, and even insects. Researchers are increasingly finding that the reasons such behaviors evolved are as varied as the animals themselves.

The always excellent New Scientist has an article synthesizing much of the research into same-sex sexual behavior in animals and the possible evolutionary explanations. They spoke with University of California evolutionary biologists Marlene Zuk and Nathan Bailey, who recently published a paper examining same-sex behavior in various species. Zuk and Bailey note that same-sex sexual behavior in other animals can't necessarily be equated with sexual orientation in humans, researchers have come up with similar questions as to why certain animals have evolved to include members who expend energy on same-sex liaisons.

Evolutionary biologists have come up with various hypotheses for why same-sex behavior has evolved in various animals. In some cases, same-sex behavior has emerged as a result of specific adaptations, such as to foster social bonding, or because certain genes for same-sex attraction hold another survival benefit when only one copy is present. In some cases, though, the behavior is incidental, such as in certain fish that cannot easily tell male and female members apart.

Below, New Scientist charts several of the possible evolutionary explanations for same-sex sexual behavior in various species:

Bailey believes that exploring the evolution of sexual behavior will give us a better understanding of evolution, including the development of our own species:

"Given its persistence in species in many different animal groups, including humans, viewing it as an evolutionary force in its own right promises to provide a much richer understanding of the evolution of reproductive behaviour," Bailey says. He suggests we could make some fascinating comparisons. Might male-male copulation in species as diverse as flour beetles and dolphins have similar, even predictable, evolutionary consequences? More daringly, could understanding the evolutionary consequences of same-sex interactions in animals help us understand our own evolution?

Homosexual selection: The power of same-sex liaisons [New Scientist]

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<![CDATA[Could New Therapies For Drug-Resistant Staph Help To Breed Even Worse Mutant Super-Bacteria?]]> Antibiotic-resistant staph bugs are a terrifying prospect: a potentially deadly skin infection that resists most traditional treatments. But now, researchers think they've found a weapon against MRSA: hitting it with low-temperature plasma.

One set of researchers from the Max Planck Institute for Extraterrestrial Physics are trialling a device for quickly disinfecting human skin using low-temperature plasma, which would save a significant amount of time, compared to traditional hospital scrubbing.

The second is an "argon plasma torch", developed with ADTEC Plasma Technology Ltd in Japan, for disinfecting chronic non-healing wounds. This terrifying sounding device can specifically target bacteria but is harmless to human cells.

MRSA (Methicillin-resistant Staphylococcus aureus) arose as such a threat because it is mutation that is resistant all but the most powerful antibiotics. It can prove lethal if it spreads to your heart or other key organs. But finding stronger treatments against MRSA may not be the best long-term solution — by attacking the bugs with plasma, we may ensure that the mutations that survive will be even tougher. We're effectively breeding Fremen bacteria.

[via the Institute of Physics]

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<![CDATA[Give Me A Biotech Apocalypse That I Can Believe In]]> So Hollywood trashed the world in 2012, and scourged it in The Road. But neither apocalypse delivered the sweet tang of satisfaction. That's because what the Earth needs now are life-distorting biotech mutation stories. Here's why.

First of all, there haven't been very many biotech apocalypse flicks at all, even though genetic engineering and other genome/proteome-based weirdness are freaking everybody out in the pop science media. Possibly 28 Days Later is the iconic example of a biotech apocalypse, since it's a human-made virus that unleashes the zombie hoardes. But honestly, we can do better than plagues - we've all seen those before. Besides, the upcoming World War Z movie is probably going to hold the whole plague subgenre hostage to its awesomeness next year.

So what would have to happen to produce a really great biotech apocalypse that wasn't just a virus scare with zombies that made us all think disappointedly of I Am Legend?

First of all, the biotech armageddon would have to affect the entire biosphere, not just humans. When it comes to imagining this scenario I always think of Kathleen Ann Goonan's Jazz Quintet novels, which begin with Queen City Jazz. She creates a future where many people move into biotech cities whose entire infrastructure is mutable and organic - genetically-engineered bees keep the cities "growing" by fertilizing the buildings, which are actually giant wildflowers. The problem comes when the city itself is infested with a virus that causes its entire fabric to remake itself to resemble stories from files stored in the city's library. What if your city decided that it wanted to be a film noir Paris, and then reprogrammed every person and building to emulate that (fictional) place?

If you wanted to go even weirder, visit the scenarios that Rudy Rucker comes up with in Hylozoic, where every object on the planet becomes sentient. Suddenly you are having an emotional relationship with your telephone, which has a lot of opinions about how you've abused it in the past.

I'm not saying we need movie versions of these books, though that might be nice if done by the right people. What we need is for mainstream media to catch up to what is happening in literature and in the lab.

Though I wasn't entirely crazy about Minority Report, one thing that film got right was its emphasis on believable technology. The filmmakers went to MIT, checked out labs where futuristic computer interfaces and biotech are being invented, and incorporated them into the film. I'd love to see the movie that got made after some filmmakers spent some time hanging out at the Department of Energy's Genome Research Institute, or the Max Planck Institute in Europe - or, hell, how about just reading even one essay by Drew Endy? In fact, you don't have to read - you can just watch him talk about synthetic biology here:

If researchers can genetically-engineer bacteria whose behavior changes with a flash of light, or build poplars that contain termite genes so that they break down into ethanol more easily, imagine what kind of apocalypse we're facing. That's right - it's not necessarily an apocalypse at all. It's simply a world packed with flora and fauna we couldn't possibly recognize today. In her novels Oryx and Crake and Year of the Flood, Margaret Atwood imagines that this will result in creepy half-human pigs and sheep who sprout human hair that can be sold as wigs. There is something admittedly horrifying about the idea that humanity could reshape the biosphere in its greedy, simian image. What marks the biotech apocalypse is that it's a scenario where life as we know it doesn't end - it turns into new forms of life.

What I'm saying is that I want to see stories where synthetic biology generates cities and technologies like the ones Jeff VanderMeer imagined in his recent novel Finch, where spore people grow buildings and guns from mushrooms. And I want these tales to do what few apocalyptic tales have dared to do: Explore what it means when what has been destroyed isn't the world, but instead just one instance of the world.

One of the most basic truths we learn from evolutionary theory and geology is that the world we live in - the one whose climate and landmasses we fuss about endlessly - is in fact just one version of Earth. For a long period, Earth had a different set of gasses in its atmosphere, and all life lived in the seas. The composition of our biosphere and state of our climate has changed dramatically over the millennia. C'mon Hollywood - give us a story where the world doesn't suffer apocalyptic death, but instead a dramatic rebirth. One that begins in our nanoscopic genomes, not in mega-explosions.

Image via Yanko Design

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<![CDATA[Luke Skywalker's Robotic Hand Comes Even Closer to Reality]]> Are we coming upon the era of bionic limbs? Another company has created a robotic hand that can be controlled by the wearer's thoughts and restores tactile sensation — and the subject claims it feels almost like a real hand.

An Italian research team, lead by neurologist Paolo Maria Rossini, created the LifeHand, the latest in a long line of robotic prostheses. The team performed microsurgery to attach the hand 26-year-old Pierpaolo Petruzziello, who lost much of his left hand in a car accident. Petruzziello apparently mastered the hand in just a few days, and it responded to 95 percent of his mental commands. He claims that he also received incredible sensory feedback from the hand, even registering needle pinpricks.

Several weeks ago, another team reported successful experiments with an artificial hand that provided sensory feedback, but the LifeHand team claims that the experiments with Petruzziello represent the first time a subject has made achieved such complex movements with a prosthetic using only their mind. It's also the longest a subject has worn such a prosthetic; Petruzziello wore the LifeHand for a month. More research is needed, however, before a prosthetic can be tested long-term.

Perhaps the most impressive aspect of the LifeHand is that it didn't require Petruzziello to learn any new neurological tricks. He simply sends the same sorts of signals to the robotic hand as he sends his right hand, and gets nearly the same result.


The bionic hand controlled by thoughts [Sun via DVICE]

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<![CDATA[The Mystery of Titan's Methane Lakes - Solved?]]>
Saturn's atmosphere-shrouded moon Titan is dotted with methane lakes, giving it a geography like Saskatchewan or the Great Lakes region in the US. But why are all the lakes grouped in the northern hemisphere of the moon?

Scientists at Caltech think they may have uncovered the reasons for Titan's extremely odd lake arrangement. Data gathered by the Cassini orbiter showed 20 times more area in the Northern extremities were covered by liquid ethane and methane, when compared to the South. The researchers, headed by Oded Aharonson, think that the transport of methane northwards may be due to the elliptical orbit of Saturn, and hence Titan.

Over the course of one Titan year (29.5 Earth years), the Northern hemisphere summer is long and mild, but the Southern hemisphere version is short and intense. That's because in the Southern summer season Titan is around 12% closer to the sun. While this doesn't make a huge difference over the course of a year, it does over a longer time period: It's possible that these uneven seasons result in methane evaporating in the south, drifting northward in the clouds, and then raining prodigiously in the milder north.

Around 32,000 years ago, the situation would have been reversed, with the hydrocarbons traveling Southward instead of North.

This theory is being published in this month's Nature Geoscience. Other possible explanations for the lakes include the idea that there is some (as yet unknown) fundamental difference between the hemispheres. It's also possible the methane transfer happens every season, not gradually.

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<![CDATA[Paralyzed By Light]]> Just one beam of ultra-violet light left this nematode worm completely paralyzed. A second beam of visible-spectrum light allowed it to move again. That's right - scientists have created behavioral "light switches," a way to control animals with light.

We've written about this kind of work before, specifically the research into optogenetics, which allows scientists to genetically-engineer light-sensitive reactions in animals or plants. What's different about this nematode experiment, however, is that no genetic engineering was involved - the little worm just ate a small amount of a chemical (basically the equivalent of popping a pill).

According to National Geographic:

After feeding a light-sensitive chemical to transparent, microscopic worms called nematodes, scientists at Simon Fraser University in British Columbia were able to paralyze the tiny creatures by exposing them to UV light. The paralysis works because UV light changes the structure of the ingested chemical, called dithienylethene.

Upon UV exposure, the normally clear chemical turns blue, and it shuts down the worms' metabolism, said study co-author Neil R. Branda. A shot of visible light restored the worms to normal, and the animals slowly began to wiggle around "as if they had never been paralyzed," the study authors say.

Will we be seeing the equivalent kinds of experiments taking place with humans? Yes indeed, though not for paralyzing people. Researchers are interested in light-activated medicines, which only get activated when exposed to light. This would allow doctors to activate drugs in very precise places in your body.

via NatGeo (thanks to Marilyn Terrell)

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<![CDATA[Mice With Two Mothers and No Father Live Longer]]> What happens when mammals have two mothers? In the case of mice, it seems that they live longer than mice with one male and one female parent. It could help explain why women typically live longer than men.

Researchers in Japan manipulated mouse eggs to grow mice that were bi-maternal, having genetic material from two female parents, but no male parent. They then studied these mice alongside mice with one male and one female parent. The bi-maternal mice and the control mice were kept in the same conditions and fed the same diet, but the bi-maternal mice were significantly smaller and lighter, seemed to have better immune systems, and had an average lifespan 186 days longer than the control mice.

Tomohiro Kono from the Tokyo University of Agriculture, one of the researchers, believes that the bi-maternal mice might have lived longer because of the absence of a gene mice inherit from their fathers, though further study is needed:

"We believe that the most likely reason for the differences in longevity relates to the repression of a gene called Rasgrf1 in the BM mice. This gene normally expresses from the paternally inherited chromosome and is an imprinted gene on chromosome 9 associated with post-natal growth. Thus far, it's not clear whether Rasgrf1 is definitively associated with mouse longevity, but it is one of the strong candidates for a responsible gene. Furthermore, we cannot eliminate the possibility that other, unknown genes that rely on their paternal inheritance to function normally may be responsible for the extended longevity of the BM mice."

If Rasgrf1 is responsible for mouse longevity, it could be responsible for human longevity as well, and could go a long way toward explaining why women tend to live longer than men.

Why Females Live Longer Than Males: Is It Due to the Father's Sperm? [Science Daily — Thanks to Robert Atlas]

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<![CDATA[Naked Mole Rats' Latest Superheroic Feat: Surviving Without Oxygen]]> Ugly though they may be, the naked mole rat might be the animal kingdom's greatest superhero. And their most recently discovered superpower — the ability to survive lengthy periods of oxygen deprivation — could help save human brains.

An upcoming paper in NeuroReport details the latest research on the remarkable abilities of naked mole rats. Mole rats, who live in underground tunnels where oxygen is low, are uniquely capable of surviving for lengthy periods without oxygen — and avoid suffering brain damage. Researchers at the University of Illinois at Chicago found that naked mole rats can endure more than half an hour of extreme oxygen deprivation without damage to their brain cells. At the outset, their neurons maintain function six times longer than mouse neurons do in similar circumstances. The hope is that learning more about the mechanism that preserves mole rat brains could someday prevent brain damage in victims of stroke, heart attack, drowning, and other incidences of oxygen deprivation.

This isn't the first remarkable ability the mole rats have shown. The creatures live longer than any other rodent, are apparently impervious to pain, and, as we mentioned a few weeks ago, are completely immune to cancer.

Suddenly, the choice of animal sidekick in Kim Possible makes so much more sense.


Naked Mole Rats Survive Extreme Oxygen Deprivation [LiveScience]

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<![CDATA[Vat-Grown Meat Alive in the Lab, But Not Ready to Eat]]> Want real meat that's completely cruelty free? For the first time, scientists have grown a pork chop in a laboratory, a breakthrough that could lead to a future of meat that could be harvested without killing animals.

Researchers at Eindhoven University, backed by funding from a sausage manufacturer and the Dutch government, have grown pork from cells harvested from a live pig. Although meat from goldfish has been grown from a lab, this is the first time mammal meat has been grown in-vitro.

The researchers harvested myoblasts from the muscles of a live pig. These cells are programmed to repair damage and grow into muscle, and the team was able to culture a mass of muscle cells by incubating the myoblasts in a nutrient-rich "broth." The resulting meat is a bit soggy, and needs exercise to be as tough as the meat that comes from a once-living animal, but the team is looking for ways to "train" the meat and improve its texture. They are also looking to create a synthetic version of the incubation broth, which is current made from the blood products of animal fetuses.

Laboratory rules prevent anyone from actually tasting the meat, so we don't yet known how the flavor of soggy, lab-grown meat compares to that grown on pigs. But the researchers believe that in-vitro meats could be available to consumers in as little as five years. Cue the references to Arthur C. Clarke's story "The Food of the Gods."

But at least real science has nearly caught up to Veridian Dynamics:


Scientists grow pork meat in a laboratory [Times Online]

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<![CDATA[Beautiful and Terrifying Creatures From The Edge Of Light]]> Deep in the ocean, beyond where light reaches, thousands of new species are being documented by the Census Of Marine Life. From the tiny and adorable to the nightmarish, all of these creatures from the Cthulian depths are entrancing.

The photic zone is an area of the ocean that extends beyond the reach of sunlight, as deep as 5,000 meters. For the first time, a serious effort has begun to try and catalogue the vast array of deep sea life, under the auspices of the Census Of Marine Life (COML). Currently, they've identified more than 17,000 species inhabiting the dark depths, which will join with information from hundreds of other projects next October to reveal the complete results of the census.

Most of these creatures survive on marine snow—particles of decaying plants and animals that descend to the ocean floor. This transparent sea cucumber was found at 2,750m, creeping forward at a rate of 2 cm per minute, sweeping detritus into its mouth.

[via COML]

Photos courtesy of Larry Madin, Woods Hole Oceanographic Institution.





The tiny copepod, from the Atlantic.
Image © Büntzow/Corgosinho

One of the dumbo octopods, which can grow up to five feet in length.
Photo by David Shale



The jewel squid has tiny light organs all along its body, which emit and perceive light.

This is only the fifth ever found Neocyma, discovered between 2,000 and 2,500m. Image from David Shale.

The northern comb jelly has oscillating lights up and down its length.



The snake pipefish

The "wildcat" tubeworm, which drills for oil, then dines on the chemicals inside when it hits a small well.

It wouldn't be the deep sea without nightmare fuel. Like the loosejaw, with its extendible lower jaw and red-light sensitive eyes.

Or the swallower.

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<![CDATA[New Evidence Points to Fossilized Life on Mars]]> Thirteen years ago, a team of researchers studying the Allan Hills meteorite found evidence that the rock might contain fossils of Martian bacteria. Now, fresh evidence makes a stronger case that Mars once contained life very similar to Earth bacteria.

Spaceflight Now is reporting that, within the next few days, NASA plans to publicly discuss new research concerning ALH 84001, the Martian meteorite found in Allan Hills, Antarctica. The research is said to strengthen the findings of the team that studied the meteorite over a decade ago and announced in 1996 that the meteorite might contain evidence of bacterial life.

The new research, detailed in a 46-page peer reviewed paper, looks at magnetic bacteria found on Earth. The researchers have closely studied magnetic bacteria and the formations they create in rocks. The bacteria leave distinctive remnants in the rock, uniquely-shaped magnetite crystals that test with a chemical purity that reflects biological, rather than geological, origins. That these remnants are unique to magnetic bacteria on Earth and are also found in the Allan Hills meteorite strongly suggests that the crystals indicate ancient bacterial life on Mars.

Critics of the original NASA report have doubted these features as reliable fossils, claiming that the shape and chemical purity could be achieved by the same thermal shock that separated the material from Mars in the first place. But new research reported in the paper disproves the thermal shock theory.

Spaceflight says that the new research isn't quite a "smoking gun," but it greatly strengthens the case for life on Mars, and could change the conversation about future NASA missions.

Martian meteorite surrenders new secrets of possible life [Spaceflight via Universe Today]

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<![CDATA[Lava Caves Filled with the Most Beautiful Excrement in the World]]> For years, scientists believed that the colorful deposits found in lava caves around the world were mineral deposits, but more recently they've discovered that the collections — ranging from blue-green drips to shimmering pink hexagons — are actually microbe poop.

At a recent meeting of the Geological Society of America, researchers announced that the colorful deposits, found in lava caves all over the world, are in fact biological in origin. Previously undetected microbes excrete waste inside the caves and the buildup of what one geomicrobiologist terms "bug poop" creates these impressive displays.

This discovery — that something long thought to be mineral turned out to be biological — has implications for researchers looking for life on Mars. Based on photos of the surface, it appears that Mars holds, or at one time held, lava caves similar to those where the microbe waste was found, and similar microbes might have thrived inside those caves. Mars researchers may want to consider taking samples of apparent mineral deposits to determine if those deposits are, in fact, "bug poop."

Lava Cave Minerals Actually Microbe Poop [National Geographic via Neatorama]





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<![CDATA[Undeterred by Time-Traveling Saboteurs, the LHC Begins Colliding]]> Take that, bread-dropping bird. Despite numerous delays and the suggestion that the Large Hadron Collider is being sabotaged from the future, the LHC is up and running. And, for the very first time, it has collided two proton beams.

Three days after the restart, CERN announced that it has circulated two beams simultaneously, and has observed proton-proton collisions. It's an exciting first step, but still a very first step:

"It's a great achievement to have come this far in so short a time," said CERN Director General Rolf Heuer. "But we need to keep a sense of perspective – there's still much to do before we can start the LHC physics programme."

It will still be a while before the LHC can go fishing for the Higgs boson, but the CERN researchers are fired up about collecting data on the proton collisions. The next step will involve altering the intensity and acceleration of the beams while getting a feel for the LHC's performance.

Two circulating beams bring first collisions in the LHC [CERN]

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<![CDATA[Gene Therapy Creates Superstrong Monkeys]]> It's not quite a supersoldier serum, but researchers have increased strength and muscle mass in monkeys with a small genetic tweak. And human trials for the technique are just on the horizon.

Muscle disease specialists at Ohio State University have been studying myostatin, the protein that regulates and curbs muscle growth. Their research found that a second protein, follistatin, can bind to myostatin, preventing myostatin from stopping muscle growth. They decided to test whether artificially introducing follistatin to the body would lead to an increase in strength and muscle mass. Using a common cold virus as a carrier, the researchers injected the follistatin gene into the thigh muscles of six macaque monkeys. The monkeys' thigh muscles grew an average of 15 percent as a result of the treatment, and one monkey experienced an incredible 78 percent increase in strength. The researchers reported in Science Translational Medicine that, after 15 months, the increases remained and that the monkeys experienced no visible side effects.

The researchers hope to start clinical trials on humans next year, with an eye toward helping people with degenerative muscular diseases. But for healthy individuals looking to increase their strength, the treatment would come at a cost: immunosuppressant drugs are a necessary component of the therapy.

Gene therapy may be used to treat muscular dystrophy [Times Online via Next Big Future via Reddit]

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<![CDATA[Get Ready for the Next Generation of Painkillers]]> Why do injuries continue to hurt, even when they are healing? New research reveals why we feel certain kinds of post-injury pain - and possibly how to stop it.

A group of researchers in San Francisco published a paper in this week's Nature that explores one of the many mysteries about pain: Why do light touches near a recent injury feel so painful? The answer is more complicated than you might think. These post-trauma pains, called "mechanical pain," may be caused by a different mechanism than pain associated with injury itself. The researchers discovered that mechanical pain sensations are delivered from the injury site to the spinal cord via a chemical process that can easily be interrupted - just by blocking production of a protein called VGLUT3.

They based their analysis on experiments that proved mice lacking VGLUT3 experienced far less mechanical pain than their VGLUT3-producing cohort.

What this finding suggests is that we might be on the verge of discovering a new breed of painkillers that don't depress the entire nervous system (and fuzz out your brain), but instead interrupt specific pain pathways. In essence, you'd have a highly-targeted painkiller that would prevent your injuries from hurting while they heal. You could dull that pain without dulling your mind - and hopefully without addiction.

The researchers have yet to test on humans, but they do suggest that this could be a promising area of research for pain management.

via Nature

Image of VGLUT3 in inner ear cells (it's in red) via Human Molecular Genetics

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<![CDATA[Synthetic Bacteria Can Reveal Landmines]]> Tailor-made microbes could save thousands of lives a year in poor nations, but not in the way you would think. A new breed of bioengineered bacteria can spot buried explosives.

A group of students at the University of Edinburgh have engineered a bacteria that glows bright green when it comes in contact with the chemicals that leech into the soil from buried explosives. The bacteria could be mixed into a colorless solution, and sprayed over the minefield from the air, showing bright green after a few hours. This would be a great improvement over the current slow, and decidedly dangerous methods of finding mines in existing mine fields. The students who created the bacteria say it is cheap to produce, and harmless to humans and animals, though they didn't mention its effects on local plant life.

The developers explain:

We suggest that the bacteria are dropped from a low flying aircraft which will evenly disperse the bacteria across the expected landmine field. This will allow the ground to be covered in the bacteria which will then respond to any TNT or Nitrites that it discovers in the soil. After darkness, which will give the bacteria enough time to produce the proteins which emit light and EYFP, a plane could then fly over the area once again and mark down the location of any luminescence found in the soil, for further investigation. This will provide a much safer method than having a person in the field detecting the landmines.

The bacteria will be engineered with a "kill switch" will turn off their luminescence after a few hours.

While the developers of the mine sensing bacteria have no plans to commercialize their discovery, they noted that the substance would cost approximately £0.013 per square meter where it is sprayed. So this is could be a fairly low-cost solution too, depending on the size of affected areas.

The bacteria were created for the iGem contest using a technique known as BioBricking. BioBricks are chunks of DNA sequence, each of which has a known function, and can be combined with others. It's like nanoscale biological lego: each piece has a specific function, and when combined with other pieces, the larger unit retains connectivity, so it can then be fitted onto other BioBricks. It's a technique that was developed by MIT in 2003, as a way of providing a library of biological parts, with the long-term goal of producing a synthetic living organism from standard parts.

via University of Edinburgh and iGem

Image of glowing bacteria via Maker Faire.

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<![CDATA[The Strange Case of a Goat That Lived Like a Reptile]]> The now-extinct Myotragus balearicus, or "mouse goat," stood a mere 19 inches high, but its small stature is by no means its most unusual trait. Paleontologists have determined that this diminutive goat had more in common with reptiles than mammals.

In a paper published in the new issues of Proceedings of the National Academy of Sciences, researchers from the Autonomous University of Barcelona claim that Myotragus was actually similar to the crocodile in terms of its bone structure and growth. Unlike warm-blooded mammals, which generally have quick growth rates, fast movements, and fairly large brains, the mouse goat's bone structure indicates that it had a very low metabolism, slow growth rates, and smaller brains. Like crocodiles and other reptiles, the bones of the Myotragus have parallel growth lines, indicating that the creature's growth would start and stop cyclically. The bones of other mammals generally show uninterrupted growth.

The study authors believe this indicates that the Myotragus was slow-moving, like cold-blooded animals, and that it needed fewer resources to survive. This solves one of the key mysteries surrounding the goat: how it managed to thrive for 5.2 million years on Majorca, an island with extremely little food. It also helps explain why the goats died off so quickly when humans arrived on Majorca 3000 years ago. Because of its smaller, reptile-like brain, the Myotragus didn't have possess the senses many mammals posses to elude prey, making it an easy target for humans hungering for miniature goat meat.

Dwarf Goat More Reptile Than Mammal [Discovery]

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<![CDATA[French Scientists Working to Create Swine-Bird Superflu]]> Looking toward the worst case scenario for the swine flu pandemic, virologists in Lyon are attempting to create a virus as contagious as swine flu and as deadly as avian flu. Is it time to call in Bruce Willis yet?

Researchers at the Jean Mérieux/INSERM facility in Lyon, France, are working with the highly contagious H1N1 virus and its more lethal relation H5N1, better known as the avian flu. The scientists are attempting to determine if H1N1 could reassort with H5N1, blending their genetic material, and whether a resulting virus could have the worst traits of the original viruses.

There's a method behind creating this superflu. The facility has been working to anticipate the path current and future pandemics might take so that precautions and treatments can be developed. The team is attempting to determine when reassortment between the two viruses would produce a viable product, and which reassortments — if any — are likely to occur.

Jean Mérieux/INSERM is a biosecurity level four facility, and the researchers must wear spacesuit-like hazmat attire when in the lab, but the researchers must watch out for scratches and bites from the mice and ferrets used to test the virulence and transmissibility of the viruses.

Swine flu: One killer virus, three key questions [Nature via Metafilter]

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