The Great Vampire - Who fled to E-Space to escape the Rassilon's mighty bowships. (nothing's specifically mentioned about their planet of origin, but it's stated that The Timelords completely eradicated them from our universe, so we can assume it's probably no longer around)

Sutekh the Destroyer - Last of the Osirians. 'nuff said.

The Fendahl - Another ancient enemy of the Time Lords. Fearing the power of a being capable of absorbing all energy. They destroyed the Fifth Planet, hoping the Fendahl had perished too, but somehow the skull survived and projected itself to Earth.

Meglos - Ol' Cactus face was the last Zolfa-Thuran, who's entire race perished in a civil war over control of the Dodecahedron. His planet didn't actually get destroyed, but it did turn into a sandy, inhospitable craphole, and he was the only survivor, so it still counts.

The Xeraphin - This one's a bit iffy. Technically, they're an entire race of ancient beings that narrowly escaped destruction during a great war by transforming themselves into a single gestalt intelligence.

Delta - Queen of the Chimeron and last survivor of her race. Except for the egg that she carries in her backpack, and later 50's greaser Billy, who proves once and for all that guys will do *anything* for hot alien poontang.

Kane - The very next episode also features the lone survivor of his race. Kane got dumped on an ice planet with a bio-mechanical dragon to toast his ass if he got too uppity. Apparently, he was just biding his time for several million years, since when he tries to set course for his home world of Proamnon to exact his revenge, he realises he has been a prisoner so long that the planet no longer exists. He then kills himself by opening a window and re-enacting a scene from 'Raiders of the Lost Ark'

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That tragic distinction goes to Nyssa, who watched her planet Traken be destroyed by the bizarrely universe-spanning threat in Logopolis.

of course it was universe spanning. it was the held off Heat Death of the Universe ;)

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